PMID- 32428002 OWN - NLM STAT- MEDLINE DCOM- 20200731 LR - 20200731 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 15 IP - 5 DP - 2020 TI - Effects of hunger on mood and affect reactivity to monetary reward in women with obesity - A pilot study. PG - e0232813 LID - 10.1371/journal.pone.0232813 [doi] LID - e0232813 AB - Worldwide, nearly 3 million people die every year because of being overweight or obese. Although obesity is a metabolic disease, behavioral aspects are important in its etiology. Hunger changes the rewarding potential of food in normal-weight controls. In obesity, impairments related to reward processing are present, but it is not clear whether these are due to mental disorders more common among this population. Therefore, in this pilot study, we aimed at investigating whether fasting influence mood reactivity to reward in people with obesity. Women with obesity (n = 11, all mentally healthy) and normal weight controls (n = 17) were compared on a computerized monetary reward task (the wheel of fortune), using self-reports of mood and affect (e.g., PANAS and mood evaluation during the task) as dependent variables. This task was done in 2 satiety conditions, during fasting and after eating. Partially, in line with our expectation of a reduced affect and mood reactivity to monetary reward in participants with obesity accentuated by fasting, our results indicated a significant within-group difference across time (before and after the task), with monetary gains significantly improving positive affect in healthy controls (p>0.001), but not in individuals with obesity (p = 0.32). There were no significant between-group differences in positive affect before (p = 0.328) and after (p = 0.70) the task. In addition, women with obesity, compared to controls, reported more negative affect in general (p < 0.05) and less mood reactivity during the task in response to risky gains (p < 0.001) than healthy controls. The latter was independent of the level of satiety. These preliminary results suggest an impairment in mood reactivity to monetary reward in women with obesity which is not connected to the fasting state. Increasing the reinforcing potential of rewards other than food in obesity may be one target of intervention in order to verify if that could reduce overeating. FAU - Piccolo, Mayron AU - Piccolo M AUID- ORCID: 0000-0002-6882-7456 AD - Unit of Clinical and Health Psychology, University of Fribourg, Fribourg, Switzerland. FAU - Milos, Gabriella AU - Milos G AD - Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland. FAU - Bluemel, Sena AU - Bluemel S AD - Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland. FAU - Schumacher, Sonja AU - Schumacher S AD - Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland. FAU - Müller-Pfeiffer, Christoph AU - Müller-Pfeiffer C AD - Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland. FAU - Fried, Michael AU - Fried M AD - Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland. AD - Zurich Center for Integrative Human Physiology, Zurich, Switzerland. FAU - Ernst, Monique AU - Ernst M AD - Section on Neurobiology of Fear and Anxiety, National Institutes of Mental Health, Bethesda, Maryland, United States America. FAU - Martin-Soelch, Chantal AU - Martin-Soelch C AD - Unit of Clinical and Health Psychology, University of Fribourg, Fribourg, Switzerland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200519 TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Affect/*physiology MH - Body Mass Index MH - Fasting/physiology/psychology MH - Female MH - Food/adverse effects MH - Humans MH - Hunger/*physiology MH - Male MH - Mental Disorders/*physiopathology/psychology MH - Middle Aged MH - Obesity/physiopathology/*psychology MH - Overweight/physiopathology/psychology MH - Pilot Projects MH - Reward PMC - PMC7237012 COIS- The authors have declared that no competing interests exist. EDAT- 2020/05/20 06:00 MHDA- 2020/08/01 06:00 CRDT- 2020/05/20 06:00 PHST- 2019/05/03 00:00 [received] PHST- 2020/04/22 00:00 [accepted] PHST- 2020/05/20 06:00 [entrez] PHST- 2020/05/20 06:00 [pubmed] PHST- 2020/08/01 06:00 [medline] AID - PONE-D-19-12129 [pii] AID - 10.1371/journal.pone.0232813 [doi] PST - epublish SO - PLoS One. 2020 May 19;15(5):e0232813. doi: 10.1371/journal.pone.0232813. eCollection 2020. PMID- 31749750 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 10 DP - 2019 TI - Behavioral Responses to Uncertainty in Weight-Restored Anorexia Nervosa - Preliminary Results. PG - 2492 LID - 10.3389/fpsyg.2019.02492 [doi] LID - 2492 AB - Impaired decision-making under conditions of uncertainty seems to contribute to the expression and maintenance of anorexia nervosa (AN), but it is not clear whether this impairment is a disease state that would remit with treatment, or a persisting trait in patients with AN. To examine this question, a longitudinal study was conducted in 12 female inpatients with AN (age M = 22.2, SE = 1.36), before (Time-1) and after reaching a body mass index of >17.5 kg/m(2) (Time-2). Intolerance of uncertainty (IU) was assessed via a decision-making task, the wheel of fortune (WOF). Weight gain at Time-2 was accompanied with significant changes in uncertainty-related performance compared to Time-1 [(Time × Uncertainty), p < 0.05]. At Time-1, reaction times (RTs) varied in function of uncertainty, while at Time-2, uncertainty did not modulate RTs. These findings support a change in decision-making under uncertainty with successful weight-rehabilitation in AN. While IU was present in underweight patients, it became non-significant after weight restoration. CI - Copyright © 2019 Piccolo, Milos, Bluemel, Schumacher, Mueller-Pfeiffer, Fried, Ernst and Martin-Soelch. FAU - Piccolo, Mayron AU - Piccolo M AD - Unit of Clinical and Health Psychology, University of Fribourg, Fribourg, Switzerland. FAU - Milos, Gabriella Franca AU - Milos GF AD - Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, Zurich, Switzerland. FAU - Bluemel, Sena AU - Bluemel S AD - Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland. FAU - Schumacher, Sonja AU - Schumacher S AD - Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, Zurich, Switzerland. FAU - Mueller-Pfeiffer, Christoph AU - Mueller-Pfeiffer C AD - Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, Zurich, Switzerland. FAU - Fried, Michael AU - Fried M AD - Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland. AD - Zurich Center for Integrative Human Physiology, Zurich, Switzerland. FAU - Ernst, Monique AU - Ernst M AD - Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health (NIMH), Bethesda, MD, United States. FAU - Martin-Soelch, Chantal AU - Martin-Soelch C AD - Unit of Clinical and Health Psychology, University of Fribourg, Fribourg, Switzerland. LA - eng PT - Journal Article DEP - 20191105 TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC6848854 OTO - NOTNLM OT - anorexia nervosa OT - eating disorders OT - intolerance of uncertainty OT - longitudinal OT - remission OT - weight-restoration EDAT- 2019/11/22 06:00 MHDA- 2019/11/22 06:01 CRDT- 2019/11/22 06:00 PHST- 2019/06/05 00:00 [received] PHST- 2019/10/22 00:00 [accepted] PHST- 2019/11/22 06:00 [entrez] PHST- 2019/11/22 06:00 [pubmed] PHST- 2019/11/22 06:01 [medline] AID - 10.3389/fpsyg.2019.02492 [doi] PST - epublish SO - Front Psychol. 2019 Nov 5;10:2492. doi: 10.3389/fpsyg.2019.02492. eCollection 2019. PMID- 31713283 OWN - NLM STAT- MEDLINE DCOM- 20201026 LR - 20201026 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 28 IP - 1 DP - 2020 Jan TI - Altered circulating endocannabinoids in anorexia nervosa during acute and weight-restored phases: A pilot study. PG - 46-54 LID - 10.1002/erv.2709 [doi] AB - Anorexia nervosa (AN) is an eating disorder characterized by a low food intake and often exceeding exercise, leading to a particularly low body × weight proportion. Patients with AN usually report less hunger than healthy controls. Endogenous endocannabinoids (eCBs), specifically the anandamide, have been associated to hunger, as a meal initiator, but research regarding AN and eCB and inconclusive. In this pilot study, we investigated plasma levels of eCB in inpatients with AN during fasting and after eating, both during the acute AN phase and after weight recovery. After an 8-hr fasting period, blood sample was collected from all participants. After that, participants were given a muffin test meal. Blood samples for the investigation of endogenous eCBs anandamide (N-arachidonoylethanolamide [AEA]) and 2-arachidonoylglycerol (2-AG) were then collected after 120 and 240 min. Participants were only allowed to eat and drink what was offered them during the research. AN reported less hunger than controls during fasting and at the end of the experiment. Also, plasma levels of AEA were significantly smaller in AN in comparison with controls in all time points. No significant difference was found for 2-AG plasma levels. After recovery, no significant difference was found for eCB levels. These findings could be interpreted as an AEA deregulation in AN before and after food intake, which persists after weight recovery. These findings may have implications to the pharmacological treatment of AN and to relapse occurring in the disorder. CI - © 2019 John Wiley & Sons, Ltd and Eating Disorders Association. FAU - Piccolo, Mayron AU - Piccolo M AUID- ORCID: 0000-0002-6882-7456 AD - Unit of Clinical and Health Psychology, University of Fribourg, Fribourg, Switzerland. FAU - Claussen, Malte Cristian AU - Claussen MC AD - Psychiatric University Clinic, University of Zurich, Zurich, Switzerland. FAU - Bluemel, Sena AU - Bluemel S AD - Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland. FAU - Schumacher, Sonja AU - Schumacher S AD - Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland. FAU - Cronin, Annette AU - Cronin A AD - Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland. FAU - Fried, Michael AU - Fried M AD - Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland. AD - Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. FAU - Goetze, Oliver AU - Goetze O AD - Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland. FAU - Martin-Soelch, Chantal AU - Martin-Soelch C AUID- ORCID: 0000-0003-3859-9023 AD - Unit of Clinical and Health Psychology, University of Fribourg, Fribourg, Switzerland. FAU - Milos, Gabriella AU - Milos G AD - Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland. LA - eng GR - 2017.0669/Swiss Excellence Scholarship for Foreign Scholars/International GR - 320030/125333/SNSF_/Swiss National Science Foundation/Switzerland PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191111 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 RN - 0 (Endocannabinoids) SB - IM MH - Anorexia Nervosa/*blood/*therapy MH - Endocannabinoids/*blood MH - Fasting/blood MH - Humans MH - Pilot Projects MH - Young Adult OTO - NOTNLM OT - *anorexia nervosa OT - *appetite OT - *endocannabinoids OT - *fasting EDAT- 2019/11/13 06:00 MHDA- 2020/10/27 06:00 CRDT- 2019/11/13 06:00 PHST- 2019/06/08 00:00 [received] PHST- 2019/10/03 00:00 [revised] PHST- 2019/10/10 00:00 [accepted] PHST- 2019/11/13 06:00 [pubmed] PHST- 2020/10/27 06:00 [medline] PHST- 2019/11/13 06:00 [entrez] AID - 10.1002/erv.2709 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2020 Jan;28(1):46-54. doi: 10.1002/erv.2709. Epub 2019 Nov 11. PMID- 30562563 OWN - NLM STAT- MEDLINE DCOM- 20200316 LR - 20200316 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 134 DP - 2019 Mar 1 TI - Food vs money? Effects of hunger on mood and behavioral reactivity to reward in anorexia nervosa. PG - 26-33 LID - S0195-6663(18)30995-4 [pii] LID - 10.1016/j.appet.2018.12.017 [doi] AB - BACKGROUND: Previous studies using neuroimaging and behavioral measures reported altered reward processing in anorexia nervosa (AN). In addition, anhedonia states are frequently reported in AN, potentially due to the physiological stress produced by the permanent starvation. We investigated the effect of fasting and satiety on mood and reaction times to monetary rewards in AN patients and healthy controls. METHODS: Twenty-four participants with acute AN (BMI 14.4 (11.9-15.5) Kg/m(2)) and 17 age and gender matched healthy, normal weight subjects (HW) (BMI 21.8 (18.9-24.9) Kg/m(2)) performed a reward task (the wheel of fortune) involving uncertain (50/50 probability of winning high and low rewards), safe and risky (30/70 and 10/90 probabilities) categories in fasted (after an 8-h fasting period) and fed (after intake of a standardized meal) states. Data analysis was done with linear mixed models. RESULTS: AN reacted slower than HW when maximum uncertainty (50/50) was involved. Positive mood in response to winning was higher when fasting especially for HW, while negative mood in response to not winning was higher in the fed state for both groups. Still, HW were more reactive than AN to not winning a highly predictable monetary reward (10/90 safe). CONCLUSION: The data on the reaction times indicate an impaired motor response to uncertainty in AN. Mood reactivity to winning a monetary reward does not seem to be impaired in AN, however, our results suggest that negative mood in response to not winning is less adaptive in AN. Implications to clinical psychotherapy are discussed. CI - Copyright © 2018 Elsevier Ltd. All rights reserved. FAU - Piccolo, Mayron AU - Piccolo M AD - Unit of Clinical and Health Psychology, University of Fribourg, Fribourg, Switzerland. Electronic address: mayron.piccolo@unifr.ch. FAU - Milos, Gabriella AU - Milos G AD - Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland. FAU - Bluemel, Sena AU - Bluemel S AD - Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland. FAU - Schumacher, Sonja AU - Schumacher S AD - Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland. FAU - Müller-Pfeiffer, Christoph AU - Müller-Pfeiffer C AD - Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland. FAU - Fried, Michael AU - Fried M AD - Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, Switzerland. FAU - Ernst, Monique AU - Ernst M AD - Section on Neurobiology of Fear and Anxiety, National Institutes of Mental Health, Bethesda, USA. FAU - Martin-Soelch, Chantal AU - Martin-Soelch C AD - Unit of Clinical and Health Psychology, University of Fribourg, Fribourg, Switzerland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181216 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Adolescent MH - Adult MH - Anorexia Nervosa/*psychology MH - Body Mass Index MH - Fasting MH - Female MH - Humans MH - *Hunger MH - *Reward MH - Satiation MH - Young Adult OTO - NOTNLM OT - *Affect OT - *Anorexia nervosa OT - *Fasting OT - *Mood OT - *Reward OT - *Uncertainty EDAT- 2018/12/19 06:00 MHDA- 2020/03/17 06:00 CRDT- 2018/12/19 06:00 PHST- 2018/07/09 00:00 [received] PHST- 2018/12/10 00:00 [revised] PHST- 2018/12/13 00:00 [accepted] PHST- 2018/12/19 06:00 [pubmed] PHST- 2020/03/17 06:00 [medline] PHST- 2018/12/19 06:00 [entrez] AID - S0195-6663(18)30995-4 [pii] AID - 10.1016/j.appet.2018.12.017 [doi] PST - ppublish SO - Appetite. 2019 Mar 1;134:26-33. doi: 10.1016/j.appet.2018.12.017. Epub 2018 Dec 16.